Consensus statement on prevention and management of adverse effects following rejuvenation procedures with hyaluronic acid-based fillers.

Facial fillers play an important role in the correction of facial changes associated with ageing. They offer quick treatments in the outpatient setting with minimal subsequent downtime that provide predictable, natural-looking, long-lasting results. Adverse reactions after hyaluronic acid injections tend to be mild or moderate and rather temporary. However, as with all injected or implanted biomaterials, severe adverse events can occur and patients must be fully informed of potential risks prior to undergoing treatment. A panel of experts from Germany (D), Austria (A) and Switzerland (CH) developed recommendations, and this study provides the 'DACH Consensus Recommendations' from this group specifically on the use of hyaluronic acid fillers. The aim is to help clinicians recognize potential risks and to provide guidance on how best to treat adverse events if they arise. Contraindications to hyaluronic acid fillers are also detailed, and ways to prevent adverse events occurring are discussed. Hyaluronic acid-based products are claimed to be very close to an ideal tissue augmentation agent; nevertheless, profound medical, anatomical and product knowledge are of paramount importance to minimize the occurrence of adverse reactions.

Prodigious degassing of a billion years of accumulated radiogenic helium at Yellowstone.

Helium is used as a critical tracer throughout the Earth sciences, where its relatively simple isotopic systematics is used to trace degassing from the mantle, to date groundwater and to time the rise of continents. The hydrothermal system at Yellowstone National Park is famous for its high helium-3/helium-4 isotope ratio, commonly cited as evidence for a deep mantle source for the Yellowstone hotspot. However, much of the helium emitted from this region is actually radiogenic helium-4 produced within the crust by α-decay of uranium and thorium. Here we show, by combining gas emission rates with chemistry and isotopic analyses, that crustal helium-4 emission rates from Yellowstone exceed (by orders of magnitude) any conceivable rate of generation within the crust. It seems that helium has accumulated for (at least) many hundreds of millions of years in Archaean (more than 2.5 billion years old) cratonic rocks beneath Yellowstone, only to be liberated over the past two million years by intense crustal metamorphism induced by the Yellowstone hotspot. Our results demonstrate the extremes in variability of crustal helium efflux on geologic timescales and imply crustal-scale open-system behaviour of helium in tectonically and magmatically active regions.

[LipoRepair. Approach to correction of fat tissue deformities]. / LipoRepair. Behandlungskonzept bei Fettgewebsdeformitäten.

The increasing number of liposuction procedures has led to a growing number of iatrogenic fat tissue deformities, in addition to those of idiopathic, traumatic and disease-related nature. Correspondly the need for corrective procdures has incraesed. In recent years a number of methods have been developed with are minimally invasive and low-risk. LipoRepair is a treatment concept which combines several of these minimally invasive procedures in order to maximize results with maximum tissue sparing. LipoRepair is also suited to treat other fat tissue deformities. The following procedures can be employed alone or in combination: vibration-assisted liposuction, lipotransfer/liporecycling, liposhifting/ internal lipomobilization, repeated hydrodissection training subcutaneous tissue and subcision.

[Liposuction]. / Liposuktion.

Through the appropriate use of tumescent anesthesia and the use of modern instruments and techniques, liposuction surgery has become a low-risk procedure which produces predictable and aesthetically pleasing results. New indications for liposuction surgery include lipedema and cellulite. Vibration-assisted liposuction has proven to be especially gentle to the tissues. The induced tissue contraction helps to create better results in correction procedures after less-than-satisfactory liposuction. Autologous fat transfer is also firmly established as an augmentation procedure. In liporecycling, the fat obtained during reduction liposuction is used elsewhere for augmentation. New approaches in fat transfer include the microdroplet technique, flatter injection approaches and three-dimensional tissue augmentation.

Tumescent liposuction in Germany: history and new trends and techniques.

Due to the developments and changes of tumescent solution, infiltration technique, and cannulas, we perform tumescent liposuction today using up to 6-8 l tumescent solution. Total aspirate measures up to 9 l, pure fat aspired up to 5 l. Tumescent liposuction of extended areas can still be done as an outpatient procedure. The condition of patients intra- and postoperatively as well as results has improved and the predictability of outcome is more certain.

[Teratogenicity of zinc-metallibur]. / Teratogennost' tsink-metallibura.

Suisynchron-Prämix, 5 g/100 mg active principle, was administered daily to pregnant brood sows over 20 days, beginning from the 15th, 25th, 35th, 45th, and 55th days of pregnancy. The effects of Suisynchron on pregnancy were assessed by slaughter results immediately after administration as well as by farrowing results and slaughter of the newborn piglets. Suisynchron administration between the 15th and 55th day of pregnancy killed the embryos, while teratogenic effects were primarily recorded from administration in more advanced phases, say, between the 45th and 75th days of pregnancy. Teratogenicity was attributable to damage to metabolism which, in turn, had been caused by deviations in the activity of endocrine glands.

[Significance of the correlation between follicle-stimulating and luteinizing components in the pregnant mare serum--relevance to results of biotechnical regulation of reproduction]. / Znachenje sootnosheniia follikulostimuliruiushikh i liuteiniziruiushchikh komponentov v SZhK dlia rezul'tatov diotekhicheshoi reguliatsii processa razmnozheniia.

Full assessment of the correlation between follicle-stimulating and luteinising components in PMS is of greatest importance to progress in bio-engineering action to regulate reproduction processes. Biological tests ought to be developed that are of high specificity and convenient applicability to practice conditions. Studies into the components of "raw" PMS will enable high-economy and specific use of such serum in animal husbandry.